![]() ![]() A chemical reaction takes place immediately once baking soda and water come in contact. Bake the finished batter as soon as it comes together.You want to get a crumbly mixture, not a paste. Don’t over-mix the cinnamon streusel ingredients.4 tablespoons cold butter, cut into chunks.Do not over-mix or the mixture will turn into a paste. Want more streusel in the middle and on top? Easy, just stir together the below ingredients with a fork until crumbly.Expect a lumpy batter, but don’t worry, it’ll turn out okay. Whisk it thoroughly, scraping the sides and bottom of the bowl occasionally to incorporate all the ingredients, and stop once you no longer see streaks of flour. Do not over-mix the batter, or you’ll end up with tough and dry cake.If you forget to take it out of the fridge, submerge the egg in hot water for a few minutes or until it warms to room temperature. Use room temperature egg for a smoother batter.They’re so similar that the only thing that tells them apart is the cake to topping ratio.Ī crumb cake has more streusel than cake, while a coffee cake has a thicker cake and a thin layer of streusel on top. What’s the Difference Between Coffee Cake and Crumb Cake?Ĭoffee cakes and crumb cakes are both rich and buttery with a cinnamon streusel topping. It’s crazy how such a plain recipe can make the perfect afternoon delight! This recipe calls for only three ingredients, and one of them is water. The contrast between the moist cake and crumbly, buttery cinnamon streusel in the middle and on top is pure bliss. The combination of buttery cake, cinnamon, and brown sugar is a match made in heaven. Okay, I won’t keep you waiting any longer! Let’s dive in. Paired with coffee, it gets an extra 3 points. The aroma alone will make your mouth water! Nothing beats the smell of sweet cinnamon in a cake.įrom the smell to the flavor to the texture, I give this cake at least a 12 out of 10. Yes, you can make your own buttermilk if needed using vinegar (or lemon juice) and milk.Filled and frosted with a chunky, crumbly cinnamon-sugar streusel, this cake is the ultimate fall treat. Bake until a toothpick inserted in the middle comes out clean. Spoon the batter into a 9-inch springform pan and sprinkle with the crumb topping. This will help prevent you from over mixing the cake batter, which can lead to a denser cake. Cream together the butter and sugars for a few minutes or until the mixture is light and fluffy, then mix in the eggs, vanilla, and mashed banana one at a time.Īdd the dry ingredients to the wet ingredients in three increments, alternating with the buttermilk. ![]() Whisk together the dry ingredients in one bowl. Stop when the mixture begins to form crumbs. Whisk together the dry ingredients, then cut the cold butter into the mixture using your hands or a pastry cutter. Buttermilk: This helps to create a moist, tender cake.įirst, you’ll need to make the crumb topping.Bananas: I like to measure out 1 and 1/2 cups of mashed banana to be precise, but it usually equals about 4 medium bananas or 3 large bananas.Vanilla extract: Use pure vanilla for the best banana cake.Eggs: Should be room temperature before being mixed into the batter.Salt: Enhances the banana flavor and balances out the sweetness of the bananas and sugar.Baking powder & baking soda: Work together to help the cake rise in the oven.Butter: Note that you’ll need cold butter to make the crumb topping and softened butter to make the cake batter.Cinnamon: Banana and cinnamon are the best pairing! I added cinnamon to the crumb topping and the cake itself to really amp up the flavor.Sugar: I used a mixture of brown sugar and granulated sugar to add both flavor and sweetness to the cake.All-purpose flour: Make sure to spoon and level the flour so you don’t end up with a dense cake.Here’s what you’ll need to make this recipe: This easy banana cake has two components: the crumb topping and the banana cake base. And let’s be honest, it makes eating cake totally acceptable for breakfast. This recipe really takes your typical banana cake to the next level. But every now and then I love to use bananas for something a little more rich and decadent like this Banana Crumb Cake. I really love my whole wheat banana bread when I’m looking for something a little healthier. But by the end of the week, I usually have a few left that need to be used. This Banana Crumb Cake is a perfect way to use those ripe bananas!ĭo you ever end up with a bunch of overripe bananas at the end of each week? Or is that just me? I typically buy some bananas each week at the grocery store with the intention of being healthy and actually eating them. A moist banana cake topped with an easy crumb topping. ![]()
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![]() ![]() Prozone Match Analysis Deeper match analysis, player & team stats with Prozone integration More than 2,000 new animations, alongside lots of other graphical improvements and improved AI, make the Football Manager 2016 match view the best ever.Ī highlights package available to easily view other fixtures in your own competition (or others) to keep you up-to-date with everything that’s going on in the world around you. Improved Matchday Experience Match engine - 2000+ new animations, deeper set-piece control, improved AI & brand-new highlights package Get closer to the action than ever before with your own customisable character to bark out instructions and join the celebrations from the touchline. ![]() Manager on the Touchline Customise your own touchline manager character & see them and other managers on the touchline Starting with a fixed budget, each manager builds a squad from scratch, competing with other managers to sign the best talent before going head-to-head against one another in a mini-league.Ī little secret regarding Fantasy Draft mode - it's for up to 32 players. New Game Mode – Fantasy Draft Go head-to-head with mates in Fantasy Draft modeĬreate your dream team and take on your mates in ‘Fantasy Draft’ mode. Create-A-Club allows you to name the club, add yourself and a friend to the line-up, edit the squad to your heart’s content and even choose the colours. Choose a name, colours & add yourself with Create-a-Club modeįor the first time, Football Manager 2016 allows fans to add their own custom-built club to any league they choose, through the single player ‘Create-a-club’ mode. New Game Mode – Create-A-Club Replace an existing team with one of your own. We'll be updating this page whenever there is new information to be added. ![]() ![]() ![]() ![]() A careful inspection of the system and its components will help you to pinpoint the source of trouble. The system’s computer keeps the relay grounded but it can go on and off due to the bad switch. Or you can, before starting the next step of diagnosis, you should know that a low-pressure switch can create problems with the compressor clutch’s relay in some car models. If only the pulley is rotating, the compressor clutch is having an issue, which could be stemming from several sources – a blown fuse, bad clutch oil, low-pressure lockout, or an open wire in the oil. Also, find out whether the clutch and the pulley are spinning. Check the front side of the clutch to examine its condition. Set all air conditioning controls to the MAX before kicking off the engine. Lets make sure your AC is working well, and get started. It could be anything from an obstruction in the refrigerant circuit to a loose wire. We’ll talk about the possible problems and solutions for a compressor clutch that is not engaging. You may decide to check the engine coolant and the engine oil as well to rule out other issues, but the clutch if the component that must function in order for the AC to work. If the AC is not blowing cool air into the car, you may want to do a visual inspection of the AC compressor clutch and determine if you can see what might be causing the clutch to not engage.Įven if you just filled up the AC system with refrigerant, if the AC compressor can’t operate correctly, you’ll get warm air. If the compressor clutch doesn’t engage that usually means, there’s an electrical or mechanical problem with the compressor. The compressor could have a serious issue or a small one. What could be the problem? If suddenly, the AC compressor clutch stops working and doesn’t engage, this could be the reason your AC isn’t functioning properly. However, when you turn on the air conditioner it only blows warm air. 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Sony ICF-CD815 AM/FM Stereo CD Clock Radioįor a long time, Sony has been a company that many people associate with high quality. It feels quite flimsy, so be extra cautious in its use to avoid premature damage.ģ. Heads-up: Nonetheless, some people note that the radio does not hold up over time. Additionally, you can program 20 tracks, so you can personalize the music you are listening to. It has strategically laid buttons, which will be easy to access. It’s amazing when I pair it wirelessly with a tablet or smartphone and stream content from such devices.Įase of use is another benefit that you can enjoy in this CD player alarm clock. You can connect to another device in a breeze without the need for annoying wires. It is also worth noting that it works as a Bluetooth receiver. The antenna is also effective in minimizing interference. This will let you connect to different stations and expect impressive clarity. The external FM antenna is one more feature that improves the overall audio quality. Meanwhile, if you want to listen privately, it has a headphone jack. At its size, the output is surprisingly powerful. Located under the pretty grills, they help in ensuring clear and outstanding sound reproduction. More than its looks, it also stands out because of the full-range stereo speakers. It will double as a functional home accessory. Crosley CR612B-BK Corsair Tabletop AM/FM RadioĪn alarm clock CD radio should not be boring! That said, if you want something beautiful, you will appreciate the retro-inspired look of this model. You need to study the manual comprehensively to use the radio without a problem.Ģ. The buttons are not laid out strategically and are not intuitive. Heads-up: However, one of the drawbacks is that it is quite confusing to use. You can even connect it to smart devices using the auxiliary input jack. Plus, it has different functions, including skip, search, forward, and back. The radio has a top-loading CD player, making it easy to insert a disc. The alarm also has sleep and snooze functions. Your favorite songs can be the perfect background music to wake up to. Aside from waking up through the alarm beep, you can also do so through automatic radio tuning or CD playback. It also has an incredible clock function. When you wake up in the middle of your sleep and all lights are turned off, you won’t have a problem seeing the time. The backlit digital display is highly visible, even at night. More so, it has a multifunctional 6-inch green LED. You do not need to search for them every time you want to listen. Not to mention, it has ten AM and ten FM presets for easy access to your favorite stations. It locks at accurate frequencies while also eliminating the need for manual tuning. It has an electric circuit that compares a reference signal to an input frequency and phase. Looking at its great features, we’re most likely to fall in love with digital phase-locked loop tuning (PLL). From your favorite songs to the latest news, this radio offers a remarkable listening experience. Jensen JCR-310 Dual-Alarm Clock RadioĪs you look for an alarm clock with a CD player, this should be on the top of your list. Can I Connect My Smartphone to the Radio.How Do I Set the Time on My CD Clock Radio.What Clock Radio Has the Best Sound Quality.What to Look for When Buying CD Clock Radio.HANNLOMAX 8541745843 HX-300CD CD Player Clock Craig CM427 Vertical CD Stereo Shelf System ![]() G Keni CD Player Boombox Dual Alarm Clock Sony ICF-CD815 AM/FM Stereo CD Clock Radio Crosley CR612B-BK Corsair Tabletop AM/FM Radio ![]() ![]() ![]() Each of these atoms is bonded to the central carbon atom, forming a tetrahedral shape. In CH2Cl2, the carbon atom is bonded to two chlorine atoms and two hydrogen atoms. The molecular geometry of CH2Cl2 can be determined by analyzing the arrangement of atoms and lone pairs around the central carbon atom. Determination of the shape of CH2CL2 molecule This means that the molecule has a positive and negative end, and it can interact with other polar molecules through dipole-dipole interactions. The asymmetrical distribution of electrons in the molecule makes it polar. As a result, the molecule has a dipole moment, with a partial negative charge on the chlorine atoms and a partial positive charge on the hydrogen atoms. In CH2Cl2, the carbon atom is bonded to two chlorine atoms and two hydrogen atoms, resulting in a tetrahedral shape with a dipole moment.Ĭhlorine has a higher electronegativity than carbon and hydrogen, which means that the electrons in the covalent bonds are pulled more towards the chlorine atoms. The polar/non-polar nature of the CH2Cl2 molecule can be explained by analyzing the electronegativity difference between the atoms in the molecule. Explanation of the polar/non-polar nature of CH2CL2 molecule Calculate the formal charges of each atom in the molecule to confirm the accuracy of the Lewis structure.Ĭ.In CH2Cl2, each atom has a complete octet or duet. Check that all atoms have a complete octet of valence electrons, except for hydrogen, which can only have two.In CH2Cl2, there are two remaining valence electrons, which are placed as a lone pair on the central carbon atom. ![]()
![]() Wake up and picture the people and things that you are grateful for starting your day. The best advice I’ve ever received is to be in gratitude. Before each show, we all huddle up, put our hands in and shout, “Oooh, girl!”Ģ5. I can’t leave home without my DemerBox! It charges my phone, keeps all my stuff together, floats and plays music for hours without having to charge it. My favorite part of Georgia is up in the Appalachian Mountains, on a river.Ģ3. I also love hiking and being outdoors.Ģ2. I can get on there and play Madden for an hour and be done. I’m not sure how many total hats I have, but I probably have about eight or 10 that I swap around.Ģ1.When I work out, I love my Arc Trainer. ![]() My two favorite places to vacation are Alaska and Hawaii.Ģ0. On any given Sunday afternoon, I’m likely on the water with my kids.ġ9. My favorite games to play are Fortnite and Monopoly.ġ8. My favorite actors are Woody Harrelson, Daniel Day-Lewis, Danny McBride and Zac Brown. My life motto is, “You get what you give.”ġ6. Right now, I love covering Wood Brothers songs. My favorite cover song to play is usually the newest one that we have learned. I love how it gets more worn-in over time.ġ2. My favorite item of clothing is a belt that I’ve had forever. My go-to truck stop snack food is Jack Link’s Beef Jerky.ġ1. My favorite new artist is Tenille Townes.ġ0. My favorite artist when I was growing up was James Taylor.ĩ. I couldn’t imagine a life without dogs!Ĩ. I’m always trying to get better at guitar, which is a lifelong practice.ħ. My secret talent is I like to make knives - and then I like to cook with them.Ħ. I have a lot of tattoos! I carry my art around with me. The Gorge Amphitheater in Washington State is also epic.Ĥ. The best concerts I’ve ever played were probably in Boston. I cleaned the grease machines, pots and pans.ģ. My first job was at The Wagon Wheel, which was a catfish fry house. ![]() Scroll down for 25 things you don’t know about the artist:Ģ. “I love a lot of our new songs.”īrown told Us all about his favorite things, hidden talents and more. ![]() Marcus King), off our new album, The Comeback,” he said. He once told Formula 1 star Daniel Riccardo that if he brings McLaren F1 back to the top of the podium, he’ll drink a shoey an Australian tradition. While he loves a lot of his songs - he said “Colder Weather” will always be a special one - but a certain track from his new album, The Comeback, which dropped on October 15, is a new favorite. Zak Brown is a man who keeps to his word. When he isn’t with his kids, he’s in the studio. The proud papa revealed that he loves playing Fortnite and Monopoly with his family, and they like to spend Sundays on the water. “I like teaching my kids how to do stuff,” the Georgia native told Us. The musician coparents with ex-wife Shelly Brown, from whom he split in 2018. While supporting the Zac Brown Band’s new album, The Comeback, Zac Brown himself exclusively revealed some fun facts about himself to Us Weekly.īrown, 43, is the country group’s lead singer, but when he isn’t rocking out on stage, he’s at home with his five kids - daughters Justice, 14, Lucy, 13, Georgia, 11, and Joni, 10, as well as son Alexander, 7. ![]() ![]() Together, these data suggest that KAP plays a role in normal growth control and that deregulated KAP expression may contribute to the malignant phenotypes. In addition, blocking KAP overexpression resulted in a decreased population of S-phase cells during cell cycle progression and reduced Cdk2 kinase activity. We demonstrate further that selective inhibition of KAP overexpression by an antisense approach in the HeLa and LNCaP cancer cell lines decreased their transformed phenotype in vitro and their tumorigenicity in nude mice. We report that breast and prostate malignancies are associated with high levels of KAP expression. In an effort to search for candidate genes whose function or expression is altered causally in carcinogenesis, we identified the KAP gene as an overexpressed gene in human breast and prostate cancer using differential screening. Phosphatases have also been shown to play an important role in regulating a variety of signal transduction pathways that have a bearing on cancer (reviewed in references 5, 9, 29, 31, 36, and 39). However, the physiological substrate(s) for tyrosine dephosphorylation of KAP has not yet been identified.Īccumulating evidence suggests that deregulation of protein phosphorylation is a key event in neoplastic transformation. It has been reported that KAP may inactivate a specific protein kinase, probably Cdk2 or Cdc2, by removing phosphates from the cyclin complexes, and this may contribute to cell cycle control ( 2, 24, 42). However, the biological significance of the interactions remains to be elucidated. Further studies demonstrated that kinase-associated phosphatase (KAP) binds to Cdk2 and dephosphorylates Thr160 when the associated cyclin subunit is degraded or dissociated ( 2, 42). The identification of these negative regulators of Cdks has provided key insights into how the cell cycle can be controlled.Ī Cdk-interacting protein called KAP/Cdi1 was first identified as a novel G 1- and S-phase dual-specificity phosphatase that associates with Cdk2 and/or Cdc2 ( 22, 24). Among these, the mammalian G 1 Cdk inhibitors have been shown to be involved in diverse processes such as repair of DNA damage, differentiation, tumor suppression, and cellular senescence ( 12, 22, 24, 25, 37, 52). Proteins that interact with Cdks play distinct and specific roles in cell cycle regulation. The activity of these kinases depends on their association with a family of positive regulatory protein subunits known as cyclins during the cell cycle. These controls play important roles in preventing tumorigenesis ( 26, 28, 30, 31).Ĭell cycle progression in mammals requires multiple cyclin-dependent kinases (Cdks) ( 44). The transition from one stage of the cell cycle to another is regulated by the transcription of a number of cyclin genes, the degradation of cyclin proteins, and the modification of the cyclin-dependent kinase proteins by phosphorylation (reviewed in references 11, 29, and 30). Among normal cellular functions, regulatory control of the cell cycle plays an important role in normal cell proliferation, and genetic alterations that affect cell cycle control have been shown to be associated with tumor progression (reviewed in references 26, 28, 30, 32, 44, and 46). These alterations may involve the dysregulation of a variety of normal cellular functions, leading to the initiation and progression of a tumor. Human cancer development is a multistage process that results from the stepwise acquisition of genetic alterations. These findings suggest that therapeutic intervention might be aimed at repression of KAP gene overexpression in human breast and prostate cancer. Furthermore, lowering KAP expression led to inhibition of the transformed phenotype, with reduced anchorage-independent growth and tumorigenic potential in athymic nude mice. Blocking KAP expression by antisense KAP in a tetracycline-regulatable system results in a reduced population of S-phase cells and reduced Cdk2 kinase activity. In normal cells, KAP is primarily found in the perinuclear region, but in tumor cells, a significant portion of KAP is found in the cytoplasm. Here we report that breast and prostate malignancies are associated with high levels of KAP expression. We have identified the KAP gene as an overexpressed gene in breast and prostate cancer by using a phosphatase domain-specific differential-display PCR strategy. The kinase-associated phosphatase (KAP) is a human dual-specificity protein phosphatase that was identified as a Cdc2- or Cdk2-interacting protein by a yeast two-hybrid screening, yet the biological significance of these interactions remains elusive. Accumulating evidence suggests that phosphatases play an important role in regulating a variety of signal transduction pathways that have a bearing on cancer. ![]() ![]() ![]() SketchUp comes in three subscription options: Subscription offerings and their characteristics ![]() A new site was provided, Extension Warehouse, hosting plugins and extensions for SketchUp. Trimble Navigation (now Trimble Inc.) acquired SketchUp from Google on Jfor an undisclosed sum. The building designs themselves are saved in SKP. Geolocation information is always stored in the KMZ file. SketchUp version 8 use under Wine has been rated " Gold". On September 1, 2010, SketchUp 8 was released with model geolocation with Google Maps and Building Maker integration. ![]() On November 17, 2008, SketchUp 7 was released with integration of SketchUp's Component Browser with Google 3D Warehouse, LayOut 2 and dynamic components that respond to scaling. Google SketchUp Pro 6 introduced a beta version of Google SketchUp LayOut which includes 2D vector tools and page layout tools allowing presentations to be produced without the need for a separate presentation program. On January 9, 2007, Google announced Google SketchUp 6, a free downloadable version of SketchUp, including integrated tools for uploading content to Google Earth and to the Google 3D Warehouse. Google acquired Software on March 14, 2006, attracted by Software's work developing a plugin for Google Earth. This C-130 Hercules model was made in SketchUp and rendered with Kerkythea. Many different 3D and 2D exporters are available in SketchUp for uses such as rendering. The program includes drawing layout functionality, surface rendering in different "styles", and enables placement of its models within Google Earth. Owned by Trimble Inc., the program is currently available as a web-based application, SketchUp Free, and three paid subscriptions, SketchUp Shop, SketchUp Pro, and SketchUp Studio, each with increasing functionality. SketchUp is a suite of subscription products that include SketchUp Pro Desktop, a 3D modeling Computer-Aided Design (CAD) program for a broad range of drawing and design applications - including architectural, interior design, industrial and product design, landscape architecture, civil and mechanical engineering, theater, film and video game development. MacOS 11+ (Big Sur) and macOS 10.15+ (Catalina) Įnglish, French, Italian, German, Spanish, Korean, Japanese, Brazilian Portuguese, Chinese (Simplified and Traditional) ![]() ![]() ![]() Instead of the usual hour lunch break, they ladies ate and talked for. “This transaction will also provide more opportunities for our team members to develop in their careers as we continue to grow our 57-year-old iconic brand.”ĭarden will host a conference call on the deal Thursday. They pulled into Bahama Breeze to get up on some good lunch and even better drinks. Explore menu, see photos and read 557 reviews: 'Very bad service, place was dirty. “Our strategy and operating philosophy aligns well with Darden, and we have a strong cultural fit that should ensure a smooth transition,” Henry said in the release. Book now at Bahama Breeze - Pembroke Pines in Pembroke Pines, FL. 'Before you go to the movie theater Try some appetizer. 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Cheddar’s had 165 restaurants at the time of the deal.Ĭardenas has been hinting at acquiring a restaurant chain since shortly after he became CEO, telling the Orlando Sentinel last year he would want a full-service restaurant able to make a “meaningful difference” in Darden’s future. The company last acquired Cheddar’s Scratch Kitchen in 2017 for $780 million. Darden already has 1,890 restaurants including Olive Garden, LongHorn Steakhouse, Cheddar’s Scratch Kitchen, Yard House, The Capital Grille, Seasons 52, Bahama Breeze, Eddie V’s and The Capital Burger. Market Rose Gold.jpeg WhatsApp Image at 2.46.12 PM (1). ![]() |